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AS-IV can protect against ischemic and hypoxic myocardial cell injury, inhibit myocardial . Here, we report a novel small molecule HHQ16, an optimized derivative of .AS-IV can protect against ischemic and hypoxic myocardial cell injury, inhibit myocardial hypertrophy and myocardial fibrosis, enhance myocardial contractility, improve diastolic dysfunction, alleviate vascular endothelial dysfunction, and promote angiogenesis. Here, we report a novel small molecule HHQ16, an optimized derivative of astragaloside IV, which effectively reversed infarction-induced myocardial remodeling and improved cardiac function by .
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Astragaloside IV (AS-IV) is the active ingredient of Astragalus membranaceus, which has a prominent role in cardiovascular diseases. AS-IV can protect against ischemic and hypoxic myocardial cell injury, inhibit myocardial hypertrophy and myocardial fibrosis, enhance myocardial contractility, improve diastolic dysfunction, alleviate vascular .Astragaloside IV (AS-IV), one of the major compounds from the aqueous extract of Astragalus membranaceus, is a cycloartane-type triterpene glycoside chemical. To date, many studies in cellular and animal models have demonstrated that AS-IV possesses potent protective effects in cardiovascular, lung, kidney and brain.
Astragaloside. Astragalosides are a series of related chemical compounds isolated from Astragalus membranaceus. [1] Also known as astrasieversianin, AS-IV, astraversianin XIV, or cyclosiversioside F, it is a white powder with a melting point of 284°C–285°C (Wang et al., 1987). Its molecular formula is C 41 H 68 O 14, and its theoretically .
Astragaloside IV (AsIV), a purified small molecular saponin, is one of the major and active components of Astragalus membranaceus. Studies on AsIV indicate that it has a wide spectrum of.
Astragalus, a commonly used Chinese herbal medicine, exerts protective effects on the cardiovascular system. Astragalus injection, in which AS-IV content is up to 11.30 mg/mL, has achieved good efficacy in the treatment of coronary heart disease, angina pectoris, viral myocarditis, and other CVDs. Astragaloside IV, a prime active component of Astragalus membranaceus, has potential as a neuroprotectant. Astragaloside IV (AS-IV), the main active ingredient of Astragalus, has been used as a treatment for heart failure with favorable effects, but its molecular mechanism has not been fully elucidated. Network pharmacological analysis and molecular docking revealed that Heat shock transcription factor 1 (HSF1) is a potential target of AS-IV.
Astragaloside IV was slowly cleared via hepatic clearance with a systemic clearance (CL) of about 0.004 l/kg/min. Based on the favorable pharmacokinetic properties in both rats and dogs, astragaloside IV warrants further investigation for .
AS-IV can protect against ischemic and hypoxic myocardial cell injury, inhibit myocardial hypertrophy and myocardial fibrosis, enhance myocardial contractility, improve diastolic dysfunction, alleviate vascular endothelial dysfunction, and promote angiogenesis. Here, we report a novel small molecule HHQ16, an optimized derivative of astragaloside IV, which effectively reversed infarction-induced myocardial remodeling and improved cardiac function by . Astragaloside IV (AS-IV) is the active ingredient of Astragalus membranaceus, which has a prominent role in cardiovascular diseases. AS-IV can protect against ischemic and hypoxic myocardial cell injury, inhibit myocardial hypertrophy and myocardial fibrosis, enhance myocardial contractility, improve diastolic dysfunction, alleviate vascular .Astragaloside IV (AS-IV), one of the major compounds from the aqueous extract of Astragalus membranaceus, is a cycloartane-type triterpene glycoside chemical. To date, many studies in cellular and animal models have demonstrated that AS-IV possesses potent protective effects in cardiovascular, lung, kidney and brain.
Astragaloside. Astragalosides are a series of related chemical compounds isolated from Astragalus membranaceus. [1] Also known as astrasieversianin, AS-IV, astraversianin XIV, or cyclosiversioside F, it is a white powder with a melting point of 284°C–285°C (Wang et al., 1987). Its molecular formula is C 41 H 68 O 14, and its theoretically . Astragaloside IV (AsIV), a purified small molecular saponin, is one of the major and active components of Astragalus membranaceus. Studies on AsIV indicate that it has a wide spectrum of.Astragalus, a commonly used Chinese herbal medicine, exerts protective effects on the cardiovascular system. Astragalus injection, in which AS-IV content is up to 11.30 mg/mL, has achieved good efficacy in the treatment of coronary heart disease, angina pectoris, viral myocarditis, and other CVDs.
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Astragaloside IV, a prime active component of Astragalus membranaceus, has potential as a neuroprotectant.
Astragaloside IV (AS-IV), the main active ingredient of Astragalus, has been used as a treatment for heart failure with favorable effects, but its molecular mechanism has not been fully elucidated. Network pharmacological analysis and molecular docking revealed that Heat shock transcription factor 1 (HSF1) is a potential target of AS-IV.
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